Journal: Marine Drugs

Article Title: Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata : From Extraction Methodologies to Possible Applications

doi: 10.3390/md17100556

Figure Lengend Snippet: B. bifurcata linear diterpenes and crude extracts’ biological activities.

Article Snippet: Synergistic effects with antibiotic:Against S. aureus ATCC®6538 (Gent (MIC = 32 μg mL − 1 ); Gent + Ext (MIC =16 μg mL − 1 ); Tetra (MIC = 16 μg mL − 1 ); Tetra + Ext (MIC = 8 μg mL − 1 ))Against S. aureus ATCC®43300 (Rif (MIC = 16 μg mL − 1 ); Rif + Ext (MIC < 2 μg mL − 1 ); Gent (MIC > 256 μg mL − 1 ); Gent+Ext (MIC = 16 μg mL − 1 ); Tetra (MIC > 256 μg mL − 1 ); Tetra + Ext (MIC < 2 μg mL − 1 ))Against E. coli ATCC®25922 (Rif (MIC = 32 μg mL − 1 ); Rif + Ext (MIC = 16 μg mL − 1 ); Gent (MIC > 256 μg mL − 1 ); Gent+Ext (MIC < 2 μg mL − 1 ); Tetra (MIC = 18 μg mL − 1 ); Tetra + Ext (MIC < 2 μg mL − 1 )).

Techniques: Activity Assay, In Vitro, Inhibition, Bacteria, Antioxidant Activity Assay, DPPH Assay, ABTS Assay, Infection, Control

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: ( Left ) Transmission electron microscopy (TEM) images of ( A ) mesoporous silica nanoparticles with particle sizes of 40 nm (MSNP-40) and ( B ) mesoporous silica nanoparticles with particle sizes of 100 nm (MSNP-100). ( Right ) Particle size distribution of MSNP-40 and MSNP-100 dispersed in Dubelcco’s modified eagle medium (DMEM) as measured by dynamic light scattering (DLS). The peak at 10 nm represents the fetal bovine serum (FBS) present in DMEM .

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: Transmission Assay, Electron Microscopy, Modification

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: Particle size and zeta potentials date for MSNP-40 and MSNP-100.

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: Zeta Potential Analyzer

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: Fourier transform infrared (FTIR) spectra of MSNP-40, MSNP-100, and cetyltrimethylammonium bromide (CTAB) following solvent extraction.

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: Fourier Transform Infrared Spectroscopy, Solvent, Extraction

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: ( A ) Raw data obtained from fluorescence-activated cell sorter (FACS) indicating the shift in fluorescence intensity (Note: Graphs shown are only from one sample). C1 = untreated, 401 = MSNP-40, 1001 = MSNP-100. ( B ) Uptake of rhodamine-loaded MSNP quantified by FACS ((mean ± SD, n = 3). ( p < 0.05 for MSNP-40 compared to MSNP-100). ( C – F ) Laser scanning confocal microscopy (LCMS) images of ( C , D ) untreated cells, ( E ) MSNP-40 and ( F ) MSNP-100. Nuclei were stained with DAPI (Blue), MSNP were stained with rhodamine (Green) and the cell cytoskeleton was stained with wheat germ agglutinin—Alexa fluor 633 (Red).

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: Fluorescence, Confocal Microscopy, Staining

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: Loading capacity and encapsulation efficiency of rifampicin into MSNP.

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: Encapsulation

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: Release kinetics of rifampicin from ( left ) MSNP in phosphate buffer solution (PBS) (pH 7.4) and ( right ) acetate buffer (pH 5.0) (mean ± SD, n = 3). Note: error bars are smaller than symbols.

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques:

Journal: Antibiotics

Article Title: Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

doi: 10.3390/antibiotics8020039

Figure Lengend Snippet: Efficacy of rifampicin and MSNP-Rif against SCV S . aureus (mean ± SD, n = 3). (Note: ** indicates MSNP-40 and MSNP-100 significantly different to untreated and unformulated rifampicin, p < 0.05).

Article Snippet: This is in line with recent studies that have demonstrated synergistic effects of antibiotics-loaded MSNP compared to free antibiotic at corresponding concentrations, thereby not requiring a complete release from the nanocarrier system [ , , ].

Techniques: